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Activation of plasma membrane TGR5 receptors in enteroendocrine cells by bile acids is known to regulate gastrointestinal secretion and motility and glucose homeostasis. Arm A: TT-00420 Tablet Monotherapy Phase Ib will enroll patients with preferred indications including advanced cholangiocarcinoma, small cell lung cancer, HER2-negative breast cancer including TNBC, bladder cancer, prostate cancer, thyroid cancer, gastric cancer, gallbladder cancer and other advanced solid tumors to receive TT-00420. DOI: 10. In addition to selling this item as new, we also have used or refurbished of this item in stock (subject to prior sale). Order it from your online account: Cards tab then Order a card. 01. Pomelos are an excellent source of vitamin C, fiber, and potassium. TT-00420 demonstrated good oral bioavailability and pharmacokinetic properties in mice, rats and dogs. 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